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目的在晚期肺癌局部放疗时,盐酸氨溴索的应用对减少早、晚期放射性肺损伤的发生率进行评价。方法110例晚期肺癌患者使用常规放疗(Dt60～75Gy,6～8周),随机分成两组,治疗组常规放疗同时,联合应用盐酸氨溴索;对照组单纯予以常规放疗。结果治疗后3个月、6个月和12个月,治疗组肺损伤发生率分别为23.6%、21.8%、23.6%;对照组肺损伤发生率分别为61.8%、63.6%、60.0%,两组比较差异有统计学意义(P<0.05)。治疗后2个月,治疗组和对照组的CR+PR分别为(49/55)和(47/55),SD+PD分别为(6/55)和(8/55),两组差异均无统计学意义(P>0.05)。结论在肺癌放疗时盐酸氨溴索的应用能减少早、晚期放射性肺损伤的发生率,而不影响放疗效果。
Objective To evaluate the use of ambroxol hydrochloride in reducing the incidence of early and late radiation-induced lung injury in patients with advanced lung cancer under local radiotherapy. Methods One hundred and ten patients with advanced lung cancer were treated with routine radiotherapy (Dt60 ~ 75Gy, 6 ~ 8 weeks) and were randomly divided into two groups. The patients in the treatment group received ambroxol hydrochloride at the same time, and the control group received routine radiotherapy. Results The incidence of lung injury in the treatment group was 23.6%, 21.8% and 23.6% at 3 months, 6 months and 12 months after treatment. The incidences of lung injury in the control group were 61.8%, 63.6% and 60.0%, respectively The difference was statistically significant (P <0.05). At 2 months after treatment, CR + PR in the treatment group and control group were (49/55) and (47/55), respectively, and SD + PD were (6/55) and (8/55) No statistical significance (P> 0.05). Conclusions The application of ambroxol hydrochloride in radiotherapy of lung cancer can reduce the incidence of early and late radiation-induced lung injury without affecting the radiotherapy effect.