氟喹诺酮类药物作为一种广谱、强效的抗菌剂,在临床上被广泛用于感染性疾病的治疗。在过去的20年中,一些地区由于用药不当导致某些菌属,特别是革兰阳性菌,对氟喹诺酮类耐药很快上升。20世纪90年代末开始,一些新的氟喹诺酮类药物,如莫西沙星、加替沙星及吉米沙星等相继问世,这些 Fluoroquinolones as a broad-spectrum, potent antibacterial agent is widely used clinically for the treatment of infectious diseases. Over the past two decades, certain strains of bacteria, especially Gram-positive bacteria, have been rapidly rising in some areas due to improper administration of some fluoroquinolones. Since the late 1990s, some new fluoroquinolones, such as moxifloxacin, gatifloxacin and gemifloxacin, have come out in succession