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目的 探讨周围型非小细胞肺癌 (NSCLC)的CT征象与ABH(O)血型抗原 (BGA)表达的相关性。材料与方法 对 72例经手术病理证实的周围型NSCLC患者术前进行CT扫描 ,并用SP法对肿瘤标本BGA进行免疫组化染色。结果 ( 1)肿瘤BGA表达阴性率随着病理分级的增加而增高 (P <0 .0 1) ,且在有淋巴结转移或肺外浸润组中明显升高 (P <0 .0 0 5 )。 ( 2 )CT征象中 ,肿块最大径 >3cm组其肿瘤BGA表达阴性率比≤ 3cm组高 (P <0 .0 0 5 ) ;有纵隔淋巴结增大组其肿瘤BGA表达阴性率高于无纵隔淋巴结增大组 (P <0 .0 0 5 ) ;胸膜受累胸膜外脂肪线消失组其BGA表达阴性率高于胸膜外脂肪线存在组 (P <0 .0 0 5 ) ;具有含气支气管征或空泡征的肺腺癌BGA表达阴性率低于无此征象的肿瘤 (P <0 .0 5 ) ,肿瘤BGA表达阴性组的强化曲线与阳性组间有差别 ,前者CT值在达到了强化峰值后有下降更快的趋势 (P≤ 0 .0 5 )。结论 CT显示肺癌瘤体 >3cm ,含气支气管征、空泡征、胸膜受累胸膜外脂肪线消失、肿瘤强化曲线及有纵隔淋巴结增大与肿瘤BGA表达有关
Objective To investigate the correlation between CT signs and the expression of ABH (O) blood group antigen (BGA) in peripheral non-small cell lung cancer (NSCLC). MATERIALS AND METHODS 72 patients with peripheral NSCLC confirmed by surgery and pathology were preoperatively scanned by CT and immunohistochemically stained with SP method. Results (1) The negative rate of tumor BGA expression increased with the increase of pathological grade (P <0.01), and was significantly higher in patients with lymph node metastasis or extrapulmonary infiltration (P <0.05). (2) Among the CT signs, the negative rate of BGA expression in tumors with a maximum diameter> 3cm was higher than that in ≤3cm (P <0.05). The negative rate of BGA expression in tumors with enlarged mediastinal lymph nodes was higher than that without mediastinal lymph nodes (P <0.05). The negative rate of BGA expression in pleural effusion extrapleural fat line group was higher than that in extrapleural fat line group (P <0.05), with bronchial air bronchus sign Or vacuolar sign of lung adenocarcinoma BGA negative expression rate was lower than the tumor without this sign (P <0. 05), the tumor BGA negative expression of the negative group of enhancement curve and the positive group difference, the former CT value reached the enhanced After the peak there is a tendency to decline faster (P≤0.05). Conclusions CT findings showed> 3 cm in lung cancer, with bronchial air sign, vacuole sign, disappearance of extrapleural adipose line in pleural involvement, enhancement of tumor curve and increase of mediastinal lymph nodes and expression of BGA in tumor