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作者在日本的群马地区作了一次有关接种新研制的麻疹、流行性腮腺炎和风疹(MMR)三联疫苗后发生的流行性腮腺炎性脑膜炎的调查研究。结果表明,应用由麻疹病毒AIK-C株、风疹病毒TO-336株和流行性腮腺炎病毒Urabe AM-9株组成的三联疫苗后引起的无菌性脑膜炎的发病率要比以往所报道的高。有4名儿童接种MMR疫苗后因患无菌性脑膜炎而住院引起了作者的注意。随后作者与当地医院的儿科医生合作,收集该地区在接种MMR疫苗后2个月内有脑膜炎、抽搐及腮腺炎症状和体征的患儿的急性期和恢复期脑脊液(CSF)及血液作病毒分离培养和血
The authors conducted a survey on epidemic parotid meningitis in the Gunma area of Japan following vaccination of newly developed measles, mumps and rubella (MMR) triple vaccines. The results showed that the incidence of aseptic meningitis caused by the use of a triple vaccine consisting of the measles virus AIK-C strain, the rubella virus TO-336 strain and the mumps virus Urabe AM-9 strain was higher than the previously reported high. Four children who were hospitalized for aseptic meningitis after receiving the MMR vaccine caught the attention of the authors. The authors then worked with pediatricians in local hospitals to collect acute and convalescent cerebrospinal fluid (CSF) and blood from children with meningitis, convulsions and mumps symptoms and signs in the area within 2 months after vaccination with MMR vaccine Isolation and blood culture