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目的探讨增殖细胞核抗原（ＰＣＮＡ）与小儿肾母细胞瘤及小儿好母细胞瘤不同组织类型和不同临床分期间的关系、方法对病理科存档的１８例小儿肾母细胞瘤原发病灶手术标本（石蜡块）组织进行ＰＣＮＡ免疫组化法检测，结合病理及临床资料，分析ＰＣＮＡ与病理分级和临床分期间的关系。结果小儿肾母细胞瘤组织中有高强度的ＰＣＮＡ表达（ＰＣＮＡ阳性细胞标记指数ＰＣＮＡ－ＬＩ高），与非肿瘤组织相比有显著的差异。肾母细胞瘤的不同病理分级间和不同临床分期间的ＰＣ－ＮＡ－ＬＩ均有显著的统计学差异（Ｐ＜０．０５）。结论在小儿肾母细胞瘤中有ＰＣＮＡ的高表达，而且其表达强度与肿瘤的病理分期和临床分期关系密切。表明ＰＣＮＡ的测定对小儿肾母细胞瘤的病理、临床均有意义，进而对肿瘤的预后有指示作用。
Objective To investigate the relationship between proliferating cell nuclear antigen (PCNA) and pediatric nephroblastoma and pediatric wellblastoma in different clinical types and clinical stages.Methods 18 pediatric nephroblastoma primary lesion specimens Paraffin block) tissue PCNA immunohistochemical detection, combined with pathological and clinical data, analysis of PCNA and pathological grading and clinical stage of the relationship. Results High expression of PCNA (PCNA positive cell marker index PCNA-LI) was found in pediatric nephroblastoma, which was significantly different from non-tumor tissue. There were significant differences in PC-NA-LI between different pathological grades of Wilms’ tumor and different clinical stages (P <0.05). Conclusion There is a high expression of PCNA in pediatric nephroblastoma, and its expression intensity is closely related to the pathological stage and clinical stage of the tumor. Show that the determination of PCNA pediatric nephroblastoma pathology, clinical significance, and then the prognosis of the tumor has an indicated role.