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磁共振成像(Magnetic Resonance Imaging,MRI)造影剂是用来增强正常与病变组织之间的磁共振信号对比度的一类顺磁性化学试剂,而顺磁性金属离子的配合物因有较大的磁距,能通过偶极相互作用缩短临近核的弛豫时间,这种顺磁性的化合物进入人体内后,能选择性地集中在某些组织中,且可以缩短局部组织质子的弛豫时间,增强信号强度及对比度,从而能探测出微小的病变部位。为研究这种含顺磁性物质的磁共振成像造影剂,本论文选用Gd3+、Mn2+和Fe3+分别与含芳酰胺寡聚配体H2L1和H3L2,进行络合反应,得到6种新型的含芳酰胺寡聚顺磁性金属配合物。再通过元素分析、红外、化学滴定、热重-差热分析等方法对配合物进行组成与结构表征。
Magnetic Resonance Imaging (MRI) contrast agents are a class of paramagnetic chemical agents used to enhance the contrast of magnetic resonance signals between normal and diseased tissues, whereas paramagnetic metal ion complexes have a larger magnetic moment , Can shorten the relaxation time of the adjacent nucleus through dipole interaction. The paramagnetic compound can selectively concentrate on certain tissues when it enters the human body, and can shorten the relaxation time of local tissue protons and enhance the signal Intensity and contrast, which can detect tiny lesions. In order to study the magnetic resonance imaging contrast agent with paramagnetic substance, we chose Gd3 +, Mn2 + and Fe3 + to react with the aromatic-containing oligomers H2L1 and H3L2, respectively, to obtain six novel aromatic- Poly paramagnetic metal complexes. And then by elemental analysis, infrared, chemical titration, thermogravimetry - differential thermal analysis of the composition and structure of the complex.