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目的:研究凝血、纤溶指标[凝血酶原时间(PT)、部分凝血酶活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白(FIB)、D-二聚体(D-D)、纤维蛋白单体(FM)]在孕产妇弥散性血管内凝血(DIC)诊断的临床应用价值。方法:16例产科早期DIC患者设为DIC组,82例正常妊娠妇女根据孕期分为早孕组(25例)、中孕组(22例)晚孕组(35例),并以24例正常非孕妇女为对照组,比较各组凝血、纤溶指标的变化。结果:DIC组PT、APTT、TT与其他各组比较均无统计学差异(P>0.05);D-D、FM呈现不同程度升高;妊娠组不同孕期的PT、APTT、TT与对照组比较均呈现不同程度的缩短,FIB、D-D随孕期的增长均呈现不同程度升高;FM浓度在妊娠中晚期趋向稳定。结论:妊娠期妇女血液呈现一定程度的凝血、纤溶功能亢进,对于产科早期DIC的诊断,D-D及FM有重要的临床应用价值。
Objective: To investigate the relationship between coagulation and fibrinolysis (PT, PTT, APTT, TT, FIB, DD, Protein Monomer (FM)] in the Diagnosis of Maternal Disseminated Intravascular Coagulation (DIC). Methods: Sixteen cases of early obstetric DIC were enrolled as DIC group, 82 normal pregnant women were divided into early pregnancy group (25 cases), middle pregnancy group (22 cases) and late pregnancy group (35 cases) Pregnant women as control group, comparing the coagulation, fibrinolysis changes in each group. Results: The levels of PT, APTT and TT in DIC group were not significantly different from those in other groups (P> 0.05). The levels of DD and FM were increased to some extent. The levels of PT, APTT and TT in different pregnancy groups were significantly higher than those in control group Different degrees of shortening, FIB, DD increased with different degrees of pregnancy showed increased; FM concentration tends to be stable in the second trimester of pregnancy. Conclusion: The blood of pregnant women shows a certain degree of blood clotting and hyperfibrinolysis. It has important clinical value for the diagnosis of early obstetric DIC, D-D and FM.