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含有高亲和力的异常血红蛋白的红细胞膜易遭受强度增加的氧化剂作用。已经知道,HbS对红细胞膜的亲和力增强,而像状红细细对膜脂质的过氧化作用特别敏感。正常血红蛋白的自发性自身氧化则能产生氧的自由基,而含有异常血红蛋白的红细胞却处在氧化剂强度增加的情况下。因此,作者评价了20例杂合子型镰状细胞贫血患者的红细胞抗氧化剂系统的行为。对20名男性杂合子型镰状细胞贫血患者和68名正常男性对照组的红细胞超氧物歧化酶(SOD)、过氧化氢酶与谷胱甘肽过氧物酶(GSH-Px)活性,
Erythrocyte membranes containing high-affinity abnormal hemoglobin are subject to increased oxidant effects. It is known that the affinity of HbS for the erythrocyte membrane is enhanced, whereas the redness of the image is particularly sensitive to the peroxidation of membrane lipids. The spontaneous self-oxidation of normal hemoglobin is able to produce oxygen free radicals, while the red blood cells containing abnormal hemoglobin are in the case of increased oxidant strength. Therefore, the authors evaluated the behavior of the erythrocyte antioxidant system in 20 patients with heterozygous sickle cell anemia. Erythrocyte superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px) activity in 20 male heterozygous sickle cell anemia patients and 68 normal male control subjects were measured.