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目的探讨甲状腺功能亢进症(甲亢)与肝功能损害之间是否存在相关性,为甲亢合并肝细胞损害的临床预防与治疗提供依据。方法采用回顾性调查法,收集甲亢病例209例,根据肝功能检测结果分为肝功能损害组(A组75例)和肝功能正常组(B组134例),比较两组病例的一般情况、临床表现、治疗前后的甲状腺功能指标和肝功能指标。调查结果采用t检验和χ2检验,P<0.05为差异有统计学意义。结果甲亢合并肝损害发生率为35.89%(75/209)。患者甲亢发病年龄A组明显高于B组(P<0.05);甲亢程度与肝功能损害程度呈正相关;治疗后肝功能恢复程度与甲状腺激素恢复程度呈负相关。结论甲亢性肝损害多发于年龄较大、甲亢病情较重的患者。因此,临床上应重视甲亢性肝损害和甲亢患者肝功能的检测。
Objective To investigate whether there is a correlation between hyperthyroidism (Hyperthyroidism) and hepatic dysfunction and provide the basis for clinical prevention and treatment of hyperthyroidism complicated with hepatocellular damage. Methods 209 cases of hyperthyroidism were collected retrospectively. According to the results of liver function test, the patients were divided into liver damage group (group A, 75 cases) and normal liver function group (group B, 134 cases). The general conditions of two groups were compared, Clinical manifestations, thyroid function index and liver function index before and after treatment. The test results using t test and χ2 test, P <0.05 for the difference was statistically significant. Results The incidence of hyperthyroidism complicated with liver injury was 35.89% (75/209). The age at onset of hyperthyroidism in group A was significantly higher than that in group B (P <0.05). The degree of hyperthyroidism was positively correlated with the degree of liver dysfunction. The degree of recovery of liver function was negatively correlated with the recovery of thyroid hormone. Conclusions Hyperthyroid liver injury is more common in older patients with hyperthyroidism. Therefore, the clinical should pay attention to hyperthyroidism liver damage and liver function tests in patients with hyperthyroidism.