0引言恶性肿瘤是世界范围内死亡率较高的疾病,并有逐年上升的趋势。尽管近年来不断涌现出新的抗肿瘤药物,但肿瘤的高复发性和耐药性仍不可避免肿瘤细胞的恶性增殖与一系列信号转导通路的异常激活或抑制密切相关。其中转录因子及转录辅助因子,通过核孔复合体(nuclear pore complexes,NPC 0 Introduction Malignancy is a worldwide disease with a high mortality rate and is on the rise year by year. Despite the continuous emergence of new antitumor drugs in recent years, the high recurrence and drug resistance of tumors are still unavoidable. The malignant proliferation of tumor cells is closely related to the abnormal activation or inhibition of a series of signal transduction pathways. Among them, transcription factors and transcriptional cofactors are transported by nuclear pore complexes (NPCs)