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目的 :探讨托里消毒散对调节肝癌患者细胞免疫功能的作用。方法 :选择可手术切除的肝癌患者 38例 ,随机分两组。Ⅰ组 :2 0例 ,在肝癌切除术前和术后第 7天服用中药托里消毒散 ,服药前后检测T淋巴细胞亚群 (CD3、CD4 、CD8)和肝功能〔谷草转氨酶 (AST)、谷丙转氨酶 (ALT)、直接胆红素 (DBIL)、间接胆红素 (IBIL)〕 ;Ⅱ组 :18例 ,不服用托里消毒散 ,在与Ⅰ组相应的时期检测T淋巴细胞亚群和肝功能。T淋巴细胞亚群的测定采用单克隆抗体标记直接免疫花环法。结果 :Ⅰ组患者CD3、CD4 、CD4 /CD8显著升高 ,术后AST、ALT、DBIL、IBIL降低 ;Ⅱ组无明显变化。结论 :肝癌切除术前和术后服用托里消毒散均可提高患者的细胞免疫功能 ,术后服用还可明显改善患者的肝功能。
Objective : To investigate the effect of Toli sterilizing powder on regulating cellular immune function in patients with liver cancer. Methods : 38 cases of liver cancer patients that were surgically removed were randomly divided into two groups. Group I: 20 patients were treated with Tonic Dispersion before and after the liver cancer resection. T-lymphocyte subsets (CD3, CD4, CD8) and hepatic function (aspartate aminotransferase (AST)) were measured before and after the treatment. Alanine aminotransferase (ALT), direct bilirubin (DBIL), indirect bilirubin (IBIL); Group II: 18 cases, do not take Toly disinfectant, T lymphocyte subsets were detected during the corresponding period with group I And liver function. The T-lymphocyte subsets were measured using a monoclonal antibody-directed immunization garland method. Results: The levels of CD3, CD4, and CD4/CD8 in group I were significantly higher than those in group I. Postoperative AST, ALT, DBIL, and IBIL were decreased. There was no significant change in group II. Conclusions: Before and after resection of hepatocellular carcinoma, Tory disinfectant can improve the patient’s cellular immune function. Postoperative use can also significantly improve the patient’s liver function.