HIV感染T辅助/诱导细胞,是通过病毒的包膜糖蛋白,与细胞表面的CD_4受体结合产生的。体外的HIV感染实验已证明,用抗CD_4的单克隆抗体(抗Leu-3a和OKT-4A)能有效地阻断HIV对细胞的感染。作者推测,针对抗Leu-3a或OKT4A的抗独特型抗体(Anti-Id)可以模拟CD_4受体,并能与HIV包膜糖蛋白结合。作者采用纯化的含在0.9％盐水内的抗Leu-3a,经静脉注入3—5周龄BALB/C HIV-infected T-helper / induced cells are produced by the viral envelope glycoprotein, which binds to cell-surface CD4 receptors. In vitro HIV infection experiments have demonstrated that anti-CD4 monoclonal antibodies (anti-Leu-3a and OKT-4A) are effective in blocking HIV infection of cells. The authors speculate that anti-idiotypic antibodies (Anti-Id) against Leu-3a or OKT4A mimic the CD4 receptor and bind to the HIV envelope glycoprotein. The authors used purified anti-Leu-3a in 0.9% saline to intravenously infuse 3-5 weeks old BALB / C