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目的建立双同位素标记试餐ＳＰＥＣＴ胃排空检测技术，研究健康志愿者固体、液体食物胃排空及胃内分布情况，探讨近端胃和远端胃在食物胃内分布和排空过程中的作用．方法９９ｍＴｃ植酸钠活体标记的鸡肝为固体试餐，含糖８０ｇ／Ｌ饮料２３０ｍＬ中加入１１３ｍＩｎＤＴＰＡ为液体试餐．１７例健康志愿者（男９例，女８例，年龄４５８岁±１４３岁）进食试餐后，平卧于带高能准直器的ＳＰＥＣＴ探头下，同步记录胃内两种同位素的活性变化，应用计算机程序划出全胃感兴趣区（ＲＯＩ）、近端胃ＲＯＩ和远端胃ＲＯＩ，提取同位素计数，拟合出液体和固体食物胃排空曲线，获得：①固体食物排空前的迟滞相（ｌａｇｔｉｍｅ，ＴＬ）；②固体和液体食物的近端胃半排空时间（ｐＴ５０）；③固体和液体食物的全胃半排空时间（Ｔ５０）；④远端胃内同位素最大活性（ＭＡＦ）及达到ＭＡＦ的时间（Ｔｍａｆ）．结果试餐标记物的稳定性良好．摄入试餐后液体成分很快开始排空，不存在ＴＬ，排空曲线呈指数曲线，Ｔ５０为４２ｍｉｎ±１０ｍｉｎ，ｐＴ５０为３９ｍｉｎ±１１ｍｉｎ，Ｔ５０与ｐＴ５０高度正相关（Ｐ＜００５），与远端胃内活性变化无显著相关型（Ｐ＞００５）．固体食物排空前有ＴＬ（平均?
Objective To establish double-isotope-labeled SPECT gastric emptying test technique to study the gastric emptying and intragastric distribution of solid and liquid food in healthy volunteers and to investigate the distribution and emptying of proximal and distal stomach in food effect. Method 99mTc sodium phytase live-labeled chicken liver solid test meal, sugar-containing 80g / L 230mL beverage added 113mIn DTPA liquid test meal. Seventeen healthy volunteers (9 males and 8 females, aged 45.8 ± 14.3 years) were enrolled in a test meal and were supine under a SPECT probe with a high-energy collimator to simultaneously record two types of isotopes in the stomach (ROI), proximal gastric ROI and distal gastric ROI were drawn by computer program. The isotope counts were extracted and the gastric emptying curves of liquid and solid food were fitted to obtain: (Lagtime, TL); ② proximal gastric emptying time (pT50) for solid and liquid foods; ③ total gastric emptying time (T50) for solid and liquid foods; ④ distal gastric isotope Maximum activity (MAF) and time to MAF (Tmaf). Results The stability of the test meal marker was good. After ingestion of the liquid, the liquid composition quickly began to empty. There was no TL. The emptying curve showed an exponential curve. T50 was 42min ± 10min, pT50 was 39min ± 11min, and T50 was highly positively correlated with pT50 (P <005) There was no significant correlation between distal gastric intragastric activity (P> 005). Solid food before emptying TL (average?