【摘 要】
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Nitric oxide (NO) has emerged as a potential wound therapeutic agent due to its pivotal role in the wound healing processes.Nevertheless,NO-based therapy for clinical applications is still restricted due to its gaseous state and short half-life.Here we ex
【机 构】
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College of Pharmacy,Weifang Medical University,Weifang,261053,China
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Nitric oxide (NO) has emerged as a potential wound therapeutic agent due to its pivotal role in the wound healing processes.Nevertheless,NO-based therapy for clinical applications is still restricted due to its gaseous state and short half-life.Here we exploited a wound dressing by incorporating sodium ni-troprusside doped prussian blue nanoparticals and Type I collagen into the chitosan/poly(vinyl alcohol)nanofibers through the electrospinning method.This hybrid nanofibrous scaffold possess the excellent abilities of NIR controlled NO release,photothermal therapy,and imitation of extra-cellular matrix-like architecture.These synergistic effects could enhance their anti-bactericidal effects in vitro and further-more accelerate wound healing in vivo when compared to control groups.Histological analysis demon-strated the scaffold could promote fibroblast growth and accelerate epithelialization.Moreover,no appar-ent histological toxicology and negligible damage to major organs were observed,which provided suffi-cient biosafety for in vivo application.These data indicate the fabricated hybrid nanofibrous scaffold could be used as an ideal candidate for accelerating wound healing and treating chronic wounds.
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