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目的研究卢龙地区婴幼儿腹泻病例肠道腺病毒流行病学特点。方法收集2010-2014年卢龙县儿童医院及妇幼保健院5岁以下住院患儿腹泻标本,采用PCR法检测肠道腺病毒。结果 1 880份腹泻标本检测出肠道腺病毒阳性标本119份,总阳性检出率为6.33%;男女患儿检出率分别为7.29%和4.81%,差异有统计学意义(χ2=4.59,P<0.05);<36月龄患儿占总阳性数的97.48%,患儿中位年龄为16月龄(11~24月龄),各年龄组间检出率差异无统计学意义(χ2=4.99,P>0.05);2010-2014年累计检出肠道腺病毒阳性标本不同月份间累计年均检出率差异有统计学意义(χ2=53.63,P<0.05),但肠道腺病毒感染仅在2010年10月~次年4月呈现一个明显的寒冷季节高发的流行趋势,从2012年开始无明显季节差异。结论肠道腺病毒是卢龙地区婴幼儿腹泻的重要病原,男患儿阳性检出率高于女患儿,可能与男童暴露和感染机会更多有关。
Objective To study the epidemiological characteristics of intestinal adenovirus in infants and young children with diarrhea in Lulong region. Methods Diarrhea samples from hospitalized children under 5 years of age from 2010 to 2014 in Lulong County Children’s Hospital and Maternal and Child Health Hospital were collected for detection of intestinal adenovirus by PCR. Results A total of 119 positive samples of enteric virus were detected in 1 880 diarrhea samples and the total positive detection rate was 6.33%. The detection rates of male and female children were 7.29% and 4.81% respectively, with significant difference (χ2 = 4.59, P <0.05). The children aged <36 months accounted for 97.48% of the total positive numbers, and the median age of children was 16 months (11-24 months). There was no significant difference in the detection rates among all age groups (χ2 = 4.99, P> 0.05). The accumulative average detection rate of positive intestine adenovirus from 2010 to 2014 was statistically significant (χ2 = 53.63, P <0.05) The infection showed a clear trend of high incidence in the cold season only from October 2010 to April next year, with no obvious seasonal difference from 2012 onwards. Conclusions Intestinal adenovirus is an important pathogen of diarrhea in infants and young children in Lulong region. The detection rate of positive rate in male children is higher than that in female children, which may be related to the chance of exposure and infection in boys.