妊娠糖尿病(GDM)38例,正常妊娠38例为对照,于用药前作OGTT,参照Cederholm等方法计算SII、RG,并以李氏法计算ISI,同时作血流变学和甲襞微循环检测。结果GDM组SI和ISI显著降低(P<0.01),IRG降低不明显,全血粘度和血浆粘度明显升高(P<0.01),红细胞变形指数明显下降(P<0.01),甲襞微循环加权积分显著高于正常妊娠妇女。结论GDM患者存在胰岛素抵抗和高粘血症和微循环障碍。 38 cases of gestational diabetes mellitus (GDM) and 38 cases of normal pregnancy as control. OGTT was used before treatment, SII and RG were calculated according to the method of Cederholm, ISI was calculated by Lee’s method, and hemorheology and nailfold microcirculation were also detected. Results The SI and ISI of GDM group were significantly decreased (P <0.01), while the IRG was not significantly reduced. The whole blood viscosity and plasma viscosity were significantly increased (P <0.01), the erythrocyte deformability index was significantly decreased (P <0.01) Points were significantly higher than normal pregnant women. Conclusion GDM patients have insulin resistance and hyperviscosity and microcirculation.