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奥美拉唑(omeprazole),商品名洛赛克(losec),是迄今发现的最新的,作用最强的酸分泌抑制剂。系通过选择性、非竞争性抑制壁细胞膜中的质子泵—H~+、K~+-ATP酶而产生强烈的抑制胃酸分泌作用。本药自1973年问世以来,临床已广泛用于消化性溃疡、返流性食管炎、卓-埃二氏综合征(ZES)等疾病的治疗。与H_2-受体阻滞剂比较,奥美拉唑具有缓解疼痛快、病变愈合率高及治程短等特点。一般认为,人体能较好耐受本品,无严重副作用。但近年来某些研究及大量的临床
Omeprazole, the trade name of Losec, is the newest and most potent inhibitor of acid secretion discovered to date. By selective, non-competitive inhibition of parietal cell membrane proton pump-H ~ +, K ~ + -ATP enzyme and produce a strong inhibition of gastric acid secretion. Since its publication in 1973, this medicine has been widely used in the treatment of diseases such as peptic ulcer, reflux esophagitis, Zoe-Erzurum syndrome (ZES) and other diseases. Compared with H 2 -receptor blocker, omeprazole has the characteristics of fast pain relief, high healing rate and short course of treatment. Generally believed that the body can better tolerate the product, no serious side effects. However, in recent years, some studies and a large number of clinical