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研究了中药复方痹痛康对正常小鼠T细胞免疫功能及部分炎症细胞因子的影响。结果表明 ,痹痛康大、中、小剂量组对小鼠伴刀豆蛋白A(ConA)诱导的脾脏T淋巴细胞增殖均有显著的抑制作用 ,其作用强度与强的松相似 ;可抑制小鼠腹腔巨噬细胞分泌白细胞介素 - 1(IL - 1)和肿瘤坏死因子 (TNF -α)等炎症细胞因子。其对T细胞免疫及炎症细胞因子的较强的免疫抑制作用 ,可能是该药对类风湿性关节炎有较好治疗作用的机理之一
The effect of traditional Chinese medicine compound Bitongkang on T cell immune function and some inflammatory cytokines in normal mice was studied. The results showed that the Bitongkang large, medium and small dose groups all had significant inhibitory effects on the concanavalin A (ConA)-induced proliferation of splenic T lymphocytes, and the effect was similar to that of prednisone; Murine peritoneal macrophages secrete inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF-α). Its strong immunosuppressive effect on T-cell immunity and inflammatory cytokines may be one of the mechanisms that the drug has a good therapeutic effect on rheumatoid arthritis.