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血小板减少症是利奈唑胺所致严重不良反应之一。利奈唑胺所致血小板减少症的危险因素为高龄、女性、治疗周期长、联用3种以上抗生素、基础血小板计数低、肾功能不全等。利奈唑胺引起血小板减少症的局部症状可见牙龈、鼻腔出血,紫癜等,严重者可出现胃肠道出血;全身症状则以发热、寒颤、全身酸痛、恶心、呕吐、腹痛、关节痛等常见。利奈唑胺致血小板减少症的机制可能包括骨髓抑制、免疫介导或氧化应激。维生素B6可能对利奈唑胺致血小板减少症有效,但机制尚未明确。
Thrombocytopenia is one of the serious side effects caused by linezolid. Linezolid-induced thrombocytopenia risk factors for the elderly, women, long treatment period, combined with three or more antibiotics, basal platelet count is low, renal insufficiency and so on. Linezolid caused local symptoms of thrombocytopenia visible gums, nasal bleeding, purpura, severe gastrointestinal bleeding may occur; systemic symptoms are fever, chills, body aches, nausea, vomiting, abdominal pain, joint pain and other common. The mechanisms by which linezolid causes thrombocytopenia may include myelosuppression, immune-mediated or oxidative stress. Vitamin B6 may be linezolid induced thrombocytopenia effective, but the mechanism is not yet clear.