论文部分内容阅读
目的探讨胃癌组织中Survivin和NF-κB在胃癌中的表达及其相关性,并初步探讨Survivin和NF-κB相互作用机制。方法采用免疫组织化学技术S-P法检测60例胃癌组织及相应的癌旁组织及30例胃正常组织中Survivin和NF-κB的表达情况。结果Survivin和NF-κB在胃癌中的表达呈正相关(r=0.443,P<0.05),阳性表达率明显高于癌旁组织及胃正常组织(P<0.05);而癌旁组织阳性表达率高于胃正常组织(P<0.05)。结论survivin及NF-κB在胃癌组织中特异性高表达,在癌旁组织、胃正常组织中的弱表达或不表达,提示它们可能参与了胃癌的发生与发展。
Objective To investigate the expression and correlation of Survivin and NF-κB in gastric carcinoma and to investigate the mechanism of the interaction between Survivin and NF-κB. Methods The expressions of Survivin and NF-κB in 60 cases of gastric cancer, corresponding paracancerous tissues and 30 cases of gastric normal tissues were detected by immunohistochemistry S-P method. Results The positive expression rate of Survivin and NF-κB in gastric cancer (r = 0.443, P <0.05) was significantly higher than that in paracancerous tissues and normal gastric tissues (P <0.05), while the positive expression rate of paracancerous tissues In gastric normal tissue (P <0.05). Conclusions Survivin and NF-κB are highly expressed in gastric cancer tissues and weakly expressed or not in normal tissues and paracancer tissues, suggesting that they may be involved in the occurrence and development of gastric cancer.