胰腺癌是发达国家和地区癌症相关死亡的主要原因之一,在中国的发病率也越来越高。Sp1(specificity protein1)是一个序列特异的DNA结合蛋白,在调节肿瘤细胞生长、分化、转移及血管生成过程中起重要作用。研究发现,Sp1在胰腺癌的发生、发展中发挥重要作用,可能是一个新的生物学标志,标识胰腺癌的侵袭性生物学行为,并为胰腺癌的治疗提供新的靶点。 Pancreatic cancer is one of the major causes of cancer-related deaths in developed countries and regions, and the incidence in China is also getting higher and higher. Sp1 (specificity protein1) is a sequence-specific DNA-binding protein that plays an important role in the regulation of tumor cell growth, differentiation, metastasis and angiogenesis. The study found that Sp1 play an important role in the occurrence and development of pancreatic cancer, which may be a new biological marker to identify the aggressive biological behavior of pancreatic cancer and provide a new target for the treatment of pancreatic cancer.