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硝苯吡啶(心痛定、利心平Nifedipine,Adalet Bay a 1040)是近年来报道的一种钙离子拮抗剂类的抗心绞痛新药,由于其优良的药理作用,70年代以来已在临床广泛应用。硝苯吡啶极易光解,故制成糖衣片和胶囊剂等含服或口服,在要求发挥速效时皆需咬碎。考虑到膜剂具有工艺简单、稳定性好、吸收快等优点(1),而关于硝苯吡啶膜剂的研制尚未见报道;再者为了便于病人舌下含服,迅速抢救危重病例,我们进行了硝苯吡啶的速释膜剂(以
Nifedipine (Nifedipine, Adalet Bay a 1040) is a new type of anti-anginal drug of calcium antagonists reported in recent years. It has been widely used clinically since the 1970s because of its excellent pharmacological effects. Nifedipine easily photolysis, it made of sugar-coated tablets and capsules, such as buccal or oral, are required to play quick when needed to bite. Taking into account the film has the advantages of simple process, good stability, fast absorption, etc. (1), and the development of nifedipine film has not been reported; Furthermore, in order to facilitate the patient sublingual, rapid rescue of critically ill patients, we proceed Nifedipine immediate release film (to