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家兔出血性休克再灌注（Ｓ／Ｒ）后，放免分析发现血浆内皮素逐渐升高，同失血前比较第６ｈ有显著差异（Ｐ＜０．０５），假手术组没有改变。磷脂酶Ａ_２阻断剂氯喹、磷酸萘酚喹和抗氧化剂黄芪酮于失血后再灌注前使用可抑制Ｓ／Ｒ后２ｈ内血浆内皮素增高，后两者可更明显降低Ｓ／Ｒ后３０ｍｉｎ的内皮索水平，与失血前比较差异非常好著（Ｐ＜０．０１）。同时，ＨＣＯ~－_３和碱贮备（ＳＢＣ）显著降低，上述三种药物治疗显著增加ＨＣＯ~－_３和ＳＢＣ的含量，它们在Ｓ／Ｒ后２４ｈ明显高于Ｓ／Ｒ组的水平（Ｐ＜０．０１）。结果提示，Ｓ／Ｒ后血浆内皮素上升可能与代谢性酸中毒加重有一定联系。磷脂酶Ａ_２阻断剂和抗氧化剂可能通过早期抑制内皮素的释放，从而减轻２４ｈ后代谢性酸中毒程度。
After hemorrhagic shock and reperfusion (S / R), radioimmunoassay showed that plasma endothelin gradually increased, which was significantly different from that before 6h (P <0.05), but not in sham operation group. Phospholipase A 2 blockers chloroquine, naphthoquine phosphate and antioxidants astragalus can inhibit the increase of plasma endothelin within 2h after S / R, and the latter two can significantly reduce the S / R after 30min The level of endothelin was significantly better than that before blood loss (P <0.01). At the same time, the contents of HCO ~ -_3 and SBC were significantly decreased, and the contents of HCO ~ -_3 and SBC were significantly increased by the above three drugs treatment, which were significantly higher than that of S / R group 24 hours after S / R (P < 0.01). The results suggest that plasma endothelin level rise after S / R may be related to the exacerbation of metabolic acidosis. Phospholipase A 2 blockers and antioxidants may reduce the level of metabolic acidosis after 24h by inhibiting the release of endothelin early.