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目的探讨孕妇宫颈人乳头瘤病毒(HPV)感染率及分布特征。方法检索中国期刊全文数据库、万方数据库、中文科技期刊数据库、中国生物医学文献数据库及PubMed,Medline,Embase,Web of Science英文数据库。计算孕妇宫颈的HPV总感染率,并计算7种HPV(16、6、18、11、58、31、33)型别感染率。结果共有28篇文献符合纳入标准,包含13 640名孕妇,HPV阳性检出2 294人,妊娠期妇女HPV总感染率为16.82%,其中我国孕妇宫颈HPV感染率为15.53%;孕早期、孕中期和孕晚期感染率分别为18.20%、14.38%和19.32%;孕妇年龄≤24岁时感染率较高(23.94%)。孕妇宫颈常见的HPV感染亚型及其感染率依次是16(3.86%)、6(2.45%)、18(1.80%)和11(1.76%)。结论妊娠期妇女宫颈HPV感染率较高,尤其是24岁以下的孕妇。最常见的感染亚型是16型。
Objective To investigate the infection rate and distribution of cervical human papillomavirus (HPV) in pregnant women. Methods The Chinese Journal Full-text Database, Wanfang Database, Chinese Science and Technology Periodical Database, Chinese Biomedical Literature Database and PubMed, Medline, Embase and Web of Science databases were searched. Calculate the HPV infection rate in pregnant women’s cervix, and calculate the infection rate of 7 types of HPV (16,6,18,11,58,31,33). Results A total of 28 articles met the inclusion criteria, including 13 640 pregnant women and 2 294 HPV positives. The total HPV infection rate in pregnant women was 16.82%, of which, the HPV infection rate in Chinese pregnant women was 15.53%. In the first trimester of pregnancy and the second trimester of pregnancy, And third trimester infection rates were 18.20%, 14.38% and 19.32%, respectively. The infection rate of pregnant women ≤24 years old was higher (23.94%). Cervical common HPV infection in pregnant women and their infection rates were 16 (3.86%), 6 (2.45%), 18 (1.80%) and 11 (1.76%). Conclusion The prevalence of cervical HPV in pregnant women is high, especially in pregnant women under 24 years of age. The most common subtype of infection is type 16.