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目的 :观察二咖啡酰奎宁酸抗复合因素致大鼠肝纤维化及脂质过氧化作用。方法 :采用复合因素复制大鼠肝纤维化模型 ,以血清层连蛋白 (LN)、透明质酸 (HA)、丙二醛 (MDA)、一氧化氮 (NO)含量、肝组织光镜、电镜下形态学改变为观察内容 ,探讨二咖啡酰奎宁酸的治疗作用。结果 :二咖啡酰奎宁酸能够显著降低血清LN ,HA ,MDA ,NO含量 ,明显改善肝组织炎症及纤维化状态。结论 :二咖啡酰奎宁酸具有一定的抗肝纤维化及脂质过氧化作用
OBJECTIVE: To observe the anti-hepatic fibrosis and lipid peroxidation induced by anti-complexation of dicaffeoylquinic acid in rats. Methods: The rat model of hepatic fibrosis was established by compound factors. Serum levels of laminin (LN), hyaluronic acid (HA), malondialdehyde (MDA), nitric oxide (NO) Under the morphological changes to observe the content, to explore the therapeutic effect of decaffeoylquinic acid. Results: Dicaffeoylquinic acid could significantly reduce the levels of serum LN, HA, MDA and NO, and significantly improve the liver inflammation and fibrosis. Conclusion: Dicaffeoylquinic acid has certain anti-hepatic fibrosis and lipid peroxidation