论文部分内容阅读
目的探讨新疆地区结核性脑膜炎预后的影响因素。方法回顾性整理108例确诊为结核性脑膜炎(tuberculous meningitis,TBM)的成年患者临床特点,临床表现,实验室检查结果,成像数据及治疗因素进行分析,通过单因素分析和多因素回归分析,确定患者预后的影响因素。结果老年、意识障碍和脑积水是死亡率的独立危险因素,延迟抗结核治疗与死亡率增加有关,附属的类固醇治疗2周改善症状,但超过4周的使用对死亡率没有显著影响。结论老年、TBM的晚期患者,脑积水都是TBM有不良预后的相关因素。TBM的早期诊断与治疗,包括短期使用类固醇,将有助于成人结核性脑膜炎预后的改善。
Objective To explore the prognostic factors of tuberculous meningitis in Xinjiang. Methods The clinical features, clinical manifestations, laboratory findings, imaging data and therapeutic factors of 108 adult patients diagnosed as tuberculous meningitis (TBM) were retrospectively analyzed. By univariate and multivariate regression analysis, Determining the prognostic factors of patients. Results Elderly, unconsciousness, and hydrocephalus were independent risk factors for mortality. Delayed anti-TB treatment was associated with increased mortality. Adjunctive steroid therapy improved symptoms by 2 weeks, but use beyond 4 weeks had no significant effect on mortality. Conclusions Elderly patients with advanced TBM and hydrocephalus are the related factors of poor prognosis of TBM. Early diagnosis and treatment of TBM, including the short-term use of steroids, will help to improve the prognosis of adult tuberculous meningitis.