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该文综述了近年来有关海洋无脊椎动物——柳珊瑚的化学成分与生物活性研究,收载了期间所报道的432个新化合物,包括46个倍半萜(含2个新天然产物),281个二萜(含1人工产物和4个海笔目八放珊瑚二萜),76个甾体,29个生物碱及其他(包括2个新天然产物)。根据化合物结构类型和柳珊瑚的科属分类进行阐述,对相关的生物活性做同步分析。重点阐述新骨架和复杂结构的特征、鉴定方法和可能的生源途径,对新化合物的来源和二萜的结构类型进行了分类,首次提出部分二萜骨架的中文译名。柳珊瑚的生物活性研究包括抗肿瘤(细胞毒)、抗炎、抗菌(金葡菌、结核杆菌等)、抗疟疾、抗污损等多方面,从中详细总结了对肿瘤细胞的细胞毒(或抑制)活性,并对柳珊瑚的化学和生物活性研究做相关讨论与展望,以期为我国柳珊瑚化学和生物活性研究、柳珊瑚化学生态学研究及海洋药物先导化合物的发现提供一定的参考。
This paper reviews the recent chemical composition and biological activity of the marine invertebrate, Salix psammophila, and contains 432 new compounds reported in the period including 46 sesquiterpenes (including 2 new natural products) 281 diterpenes (containing 1 artificial product and 4 octopus coral diterpenes), 76 steroids, 29 alkaloids and others (including 2 new natural products). According to the type of compound structure and the classification of the genus of Salix, the related biological activities are analyzed synchronously. It mainly focuses on the characteristics of new skeletons and complex structures, identification methods and possible biological sources, classifies the origin of new compounds and the structure types of diterpenes, and proposes the Chinese translation of some diterpene skeletons for the first time. The research on the bioactivity of Salix psammophila includes antitumor (cytotoxic), anti-inflammatory, antibacterial (Staphylococcus aureus, Mycobacterium tuberculosis, etc.), anti-malaria, anti-fouling and many other aspects. Inhibition) activity, and the chemical and biological activity of the coral do discuss and outlook, in order to provide a reference for the chemical and biological activity of the Chinese coral reed, the chemical ecology of liana coral and the discovery of lead compounds of marine drugs.