OK432(力尔凡)临床应用研究进展

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OK432(力尔凡)是由溶血性莲球菌Su株经青霉素处理、冷冻干燥制成的菌苗,在日本常用于癌的免疫治疗.OK432(力尔凡)主要通过免疫增强发挥其治疗作用.OK432(力尔凡)的治疗作用由免疫细胞介导和细胞因子介导.OK432(力尔凡)激活的中性粒细胞能够杀死IFN-γ或者TNF-α处理的癌细胞.OK432(力尔凡)诱导的中性粒细胞对自体瘤细胞的杀伤作用通过CD11b/CD18和ICAM-1之间的反应实现的.OK432(力尔凡)诱导的单核细胞能够杀死自体瘤细胞,OK432(力尔凡)抑制肿瘤生长的主要机制.OK432(力尔凡)刺激淋巴细胞后,显示出LAK细胞活性,这种激活的淋巴细胞甚至对抗NK细胞的瘤细胞都显示出活性. OK432 (Lelvain) is a bacterin made from a Su strain of Leptolysococcus suis treated with penicillin and freeze-dried. It is commonly used in cancer immunotherapy in Japan. OK432 (Lelvain) exerts its therapeutic effect mainly through immune enhancement. The therapeutic effect of OK432 is mediated by immune cells and cytokines. Activated neutrophils activated by OK432 can kill IFN-γ or TNF-α-treated cancer cells. OK432 (force (Erfan) induced neutrophil killing of autologous tumor cells through the reaction between CD11b/CD18 and ICAM-1. OK432 (Lelvain) induced monocytes kill autologous tumor cells, OK432 (Lelvain) The main mechanism of inhibition of tumor growth. OK432 (Lelvain) shows LAK cell activity after stimulating lymphocytes, and this activated lymphocyte even shows activity against tumor cells that fight against NK cells.
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