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目的探讨烟酰胺腺嘌呤二核苷酸磷酸盐氧化酶[NAD(P)H氧化酶]p22phox基因C242T多态性与冠心病的关系。方法采用病例对照研究方法,收集早发冠心病患者309例,迟发冠心病患者437例,对照470例,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)基因分型技术对p22phox基因C242T位点的多态性进行检测;采用单因素和多因素logistic回归计算p22phox基因C242T多态性与冠心病风险的OR值及95%CI。结果与对照组比较,早发冠心病组携带TC+TT基因型的个体比携带CC基因型更容易患冠心病,OR=1.58,95%CI=1.07～2.34;迟发冠心病组OR=1.48,95%CI=1.03～2.13;多因素调整后,与对照组比较,早发冠心病组OR=1.74,95%CI=1.16～2.62;2个病例组比较,携带TC+TT基因型与携带CC基因型的患病风险差异均无统计学意义。结论p22phox基因C242T多态性的T等位基因可能是冠心病的危险因素。
Objective To investigate the relationship between the polymorphism of p24php of nicotinamide adenine dinucleotide phosphate oxidase [NAD (P) H oxidase) and coronary heart disease. Methods A case-control study was conducted in 309 patients with premature coronary heart disease, 437 patients with late-onset coronary heart disease and 470 controls. PCR-RFLP genotyping The polymorphism of C242T locus in p22phox gene was detected. The OR of C222T polymorphism in p22phox gene and coronary heart disease risk was calculated by single factor and multivariate logistic regression and 95% CI. Results Compared with the control group, individuals with TC + TT genotype in premature coronary heart disease group were more likely to have coronary heart disease than those with CC genotype (OR = 1.58, 95% CI = 1.07-2.34), OR = 1.48 , 95% CI = 1.03-2.13; Compared with the control group, OR = 1.74,95% CI = 1.16-2.62 in the group of premature coronary heart disease after adjustment for multiple factors; Compared with the control group, the TC + TT genotype and the carrying There was no significant difference in the risk of CC genotype. Conclusion The T allele of p22phox gene C242T polymorphism may be a risk factor for coronary heart disease.