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文章以医药生物技术国家重点实验室免疫药物研发平台为案例,介绍了医药生物技术国家重点实验室如何围绕免疫药物研发的特点开展在专业性公共技术平台的布局、建设、管理和运行方面的经验。医药生物技术国家重点实验室在已有的分子生物学、生物化学、细胞生物学、生物信息学等分析平台基础上,按照免疫细胞的分析、分离、细胞因子高通量分析、整体动物水平免疫细胞分布分析等需求,整体规划和布局,建设完善的免疫分析检测平台。以提高保障仪器设备的使用效率和科研产出为目标,建立了科学、合理的管理制度。免疫药物研发平台以“管理保障运行,平台保障科研”为定位,科学布局和稳步建设,良好的运行和管理大大提高了医药生物技术国家重点实验室在免疫性疾病机制研究及免疫药物研发的工作水平,提升了重大项目的竞争能力、产出了一批高水平科研成果,为创新性免疫药物的开发和应用奠定了基础。
The article takes the national key laboratory of pharmaceutical biotechnology as an example, and introduces how the State Key Laboratory of Medical Biotechnology has carried out the layout, construction, management and operation of professional public technology platform based on the characteristics of immunological drug research and development . Based on the existing analysis platforms of molecular biology, biochemistry, cell biology and bioinformatics, the State Key Laboratory of Biomedicine of Medicine follows the analysis and separation of immune cells, the high-throughput analysis of cytokines, the overall level of animal immunity Cell distribution analysis and other needs, the overall planning and layout, building a sound immunoassay testing platform. With the goal of improving the efficiency of using equipment and scientific research and producing output, a scientific and reasonable management system has been established. The platform for the development of immunopharmaceuticals is based on the principle of “ensuring the operation and guaranteeing the platform and ensuring scientific research”, scientific distribution and steady construction, and the sound operation and management of the State Key Laboratory of Pharmaceutical Biotechnology has greatly enhanced the research on mechanisms of immune diseases and research and development of immunopharmaceuticals Work level, enhance the competitiveness of major projects, produced a number of high-level scientific research, and laid the foundation for the development and application of innovative immunization drugs.