CpG岛甲基化表型(CIMP)最早在1999年被提出,用于描述结肠癌中具有CpG位点异常高甲基化的亚型〔1〕。随后,许多学者致力于CIMP的研究。到目前为止,该表型在结肠癌中研究最多,在胃癌〔2〕、肺癌、肝癌〔3〕、恶性胶质瘤〔4〕、卵巢癌、子宫内膜癌〔5〕、乳腺癌、白血病等肿瘤中也有很多报道〔6-7〕。虽然已研究十余年,但由于甲基化检测方 CpG island methylation phenotype (CIMP) was first proposed in 1999, used to describe the colorectal cancer CpG sites with abnormal hypermethylation [1]. Subsequently, many scholars committed to CIMP research. So far, this phenotype has been the most studied in colon cancer and has been the most studied in gastric cancer [2], lung cancer, liver cancer [3], glioblastoma 〔4〕, ovarian cancer, endometrial cancer 〔5〕, breast cancer, leukemia Other tumors also have a lot of reports [6-7]. Although it has been studied for more than ten years, due to methylation detection side