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目的 采用离体大鼠心脏灌注模型 ,探讨吲达帕胺 (Indapamide)、硫氮酮 (Diltiazem)在心肌缺血 /再灌注过程中对心肌的保护作用。方法 SD大鼠 45只 ,随机分为吲达帕胺组、硫氮酮组、对照组 (灌注液中不含药物 )。比较三组动物在心肌缺血 30min及再灌注 30min后心电图、心肌酶 (CK、LDH) ,同时监测心功能指标的变化。结果 ①对照组在心肌缺血 /再灌注后CK、LDH含量较缺血前明显升高 (P<0 0 5 )。吲达帕胺组、硫氮酮组在心肌缺血 /再灌注后心肌CK、LDH含量较对照组明显降低 (P <0 0 1)。②吲达帕胺组、硫氮酮组于再灌注 15、30min两时点 ,冠脉流量、心肌收缩力恢复百分比显著高于对照组 (P <0 0 5 )。结论 吲达帕胺、硫氮酮对缺血 /再灌注的心肌具有保护作用
Objective To investigate the protective effects of indapamide and Diltiazem on myocardial during myocardial ischemia / reperfusion in rat heart perfusion model. Methods Forty-five Sprague-Dawley rats were randomly divided into indapamide group, azithromycin group and control group (drug-free perfusate). The electrocardiogram (ECG) and myocardial enzyme (CK, LDH) in the three groups were compared at 30min after myocardial ischemia and 30min after reperfusion, and the changes of cardiac function indexes were also monitored. Results ① The contents of CK and LDH in the control group were significantly increased after myocardial ischemia / reperfusion (P <0.05). The levels of CK and LDH in the indapamide group and the diazinone group were significantly lower than those in the control group after myocardial ischemia / reperfusion (P <0.01). ② In the indapamide group and the diazepam group, the percentage of recovery of coronary flow and myocardial contractility was significantly higher than that of the control group at 15 and 30 minutes after reperfusion (P <0.05). Conclusion Indapamide and diazinon have protective effect on myocardial ischemia / reperfusion injury