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目的 :探讨格林巴利综合征患者血液和脑脊液免疫球蛋白的改变及其临床意义。方法 :用免疫比浊法和免疫固定电泳分别对 2 0例格林巴利综合征的患者进行血清及脑脊液免疫球蛋白的测定并与 40例对照组比较。结果 :格林巴利综合征组脑脊液的免疫球蛋白、2 4hIgG合成率较对照组显著升高 (P <0 0 1) ,固定电泳检测发现格林巴利综合征组 5 5 %出现IgG型的寡克隆带 ,对照组只有 5 % ,两组比较有显著的统计学差异。病情迁延及肌力改善不明显的患者脑脊液免疫球蛋白的含量显著增高。结论 :格林巴利综合征的患者中枢神经系统有免疫球蛋白的自身合成 ,存在着体液免疫的异常。通常脑脊液免疫球蛋白的检测 ,对于判断病程和预后以及疗效的观察有着重要的意义。
Objective: To investigate the changes of immunoglobulin in blood and cerebrospinal fluid in patients with Guillain-Barre syndrome and its clinical significance. Methods: Immunoglobulin and immunoelectrophoresis were used to determine serum and CSF immunoglobulin in 20 patients with Guillain-Barre syndrome and compared with 40 control subjects. Results: In the Guillain-Barre syndrome group, the rate of 24 h IgG synthesis in CSF was significantly higher than that in the control group (P <0.01). In the Guillain-Barre syndrome group, IgG-IgG was found in 55% Clone zone, the control group only 5%, two groups were statistically significant differences. Serum immunoglobulin levels were significantly increased in patients with persistent disease and poor muscle tone. Conclusion: Guillain-Barre syndrome patients have central nervous system immunoglobulin self-synthesis, there is abnormal humoral immunity. Usually cerebrospinal fluid immunoglobulin detection, to determine the duration and prognosis and the efficacy of observation of great significance.