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目的探讨2型糖尿病患者血清直接胆红素(D-Bil)水平与心血管疾病(CVD)的相关性。方法回顾性分析280例2型糖尿病住院患者的临床资料,按照有无CVD分为糖尿病合并CVD组与糖尿病非CVD组,比较两组年龄、性别、可追溯糖尿病病程、吸烟、体质指数(BMI)、D-Bil、糖化血红蛋白(HbA1C)、血脂、血压,应用Logistic回归分析D-Bil与CVD的相关性。结果糖尿病合并CVD组年龄、可追溯糖尿病病程、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、低密度脂蛋白(LDL)高于非CVD组,D-Bil低于非CVD组(P<0.05);在调整了年龄、可追溯糖尿病病程、SBP、DBP、HbA1C、TC、LDL后,D-Bil与CVD呈负相关(OR=0.854,95%CI:0.737～0.990)。结论2型糖尿病患者D-Bil的降低可能是糖尿病合并CVD的独立危险因素之一。
Objective To investigate the relationship between serum direct bilirubin (D-Bil) level and cardiovascular disease (CVD) in type 2 diabetic patients. Methods The clinical data of 280 patients with type 2 diabetes mellitus were retrospectively analyzed. The age, gender, history of diabetes, smoking, body mass index (BMI) were compared between the two groups. , D-Bil, HbA1C, blood lipid and blood pressure. Logistic regression was used to analyze the correlation between D-Bil and CVD. Results The age, diabetic history, SBP, DBP, TC and LDL in diabetic patients with CVD were higher than those in non-CVD patients and D-Bil was lower than those without CVD (P <0.05). After adjusting for age, traceable duration of diabetes, SBP, DBP, HbA1C, TC and LDL, D-Bil was negatively correlated with CVD (OR = 0.854, 95% CI: 0.737-0.990). Conclusion The decrease of D-Bil in type 2 diabetic patients may be one of the independent risk factors of diabetes complicated with CVD.