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[目的]探讨泰兴市原发性肝癌的病因。[方法]选择360例原发性肝癌新发病例按性别、年龄和居住地进行以人群为基础1∶1配对的病例对照研究。[结果]单因素分析结果表明 ,饮沟塘水、饮酒量多、不良精神因素(受过强烈精神刺激、长期处于精神压抑状态和性格忧郁)、HBsAg阳性、肝脏病变(慢性肝炎、肝硬化)、家族肝癌史(父母、兄弟姐妹患肝癌)会增加泰兴市居民患肝癌的危险性。多因素条件Logistic回归分析结果显示 ,HBsAg阳性、慢性肝炎、肝硬化、一级亲属患肝癌和饮小麦酒量多均进入回归方程 ,其相对危险度分别为20 80、13 41、5 24、3 23和5 73。[结论]应针对上述危险因素采取预防措施
[Objective] To explore the cause of primary liver cancer in Taixing City. [Methods] 360 cases of new cases of primary hepatocellular carcinoma were selected and matched on a population-based 1:1 case-control study according to sex, age and place of residence. [Results] The results of single-factor analysis showed that there were many drinking water and drinking water in the gully ponds, and there were many unhealthy mental factors (strong mental stimulation, long-term mental depression and personality depression), HBsAg positive, liver diseases (chronic hepatitis, cirrhosis), The family history of liver cancer (parents, siblings, and liver cancer) will increase the risk of liver cancer in residents of Taixing City. Multivariate logistic regression analysis showed that HBsAg-positive, chronic hepatitis, cirrhosis, first-degree relatives, and alcohol intake in drinking wine all entered the regression equation, and the relative risk was 2080, 13 41 , 5 24, 3 23, respectively. And 5 73. [Conclusion] Preventive measures should be taken against the above risk factors