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目的探讨乙肝肝硬变患者血浆内源性一氧化氮（ＮＯ）水平及其与腹水的关系．方法测定３４名无腹水（Ａ组）、５１名有腹水（Ｂ组）的乙肝肝硬变患者及５０名健康献血员血浆内源性一氧化氮及内毒素水平，结果以ｔ检验、ｘ２检验作统计学分析。结果Ａ．Ｂ组血浆ＮＯ及内毒素水平均较献血贝明显升高（Ａ组Ｐ＜０．０５，Ｂ组Ｐ＜０．０１），Ｂ组者较Ａ组者升高显著（Ｐ＜０．０５），Ｂ组内毒素血症发生率较Ａ组高（Ｐ＜０．０５）．患者血浆内源性ＮＯ水平与内毒素水平正相关（ｒ＝０．５２８，Ｐ＜０．００１）．结论乙肝肝硬变患者腹水可能与内源性ＮＯ有关，降低血浆内源性ＮＯ水平对这些患者可能有益．
Objective To investigate the plasma level of endogenous nitric oxide (NO) in patients with hepatitis B cirrhosis and its relationship with ascites. Methods Plasma levels of endogenous nitric oxide (NO) and endotoxin (TUNEL) in 34 patients with ascites (group A) and 51 with ascites (group B) and 50 healthy blood donors were measured. The results were analyzed by t test and x2 test For statistical analysis. Results A. Plasma NO and endotoxin levels in group B were significantly higher than those in blood donation group (P <0.05 in group A, P <0.01 in group B), and those in group B were significantly higher than those in group A (P <0.05) , And the incidence of endotoxemia in group B was higher than that in group A (P <0.05). Plasma endogenous NO levels were positively correlated with endotoxin levels (r = 0.528, P <0.001). Conclusions Ascites in patients with hepatitis B cirrhosis may be related to endogenous nitric oxide, and lowering plasma endogenous nitric oxide may be beneficial for these patients.