论文部分内容阅读
系统性红斑狼疮(SLE)属系统性自身免疫病,以B淋巴细胞高度活化为特征,产生大量自身抗体与免疫复合物导致组织器官损害,但其致病机制仍未阐明。研究发现Th1/Th2细胞亚群及细胞因子在其发病的过程中发挥着重要的作用,细胞因子的异常表达将有助于判断疾病活动程度及指导临床免疫治疗。本文就以下几种细胞因子IL-10,IL-12,IL-18,IFN-γ,IL-17,IL-6的研究进展作一综述。
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, characterized by a high degree of activation of B lymphocytes, resulting in a large number of autoantibodies and immune complexes leading to tissue and organ damage, but its pathogenesis has not been elucidated. The study found that Th1 / Th2 cell subsets and cytokines play an important role in the pathogenesis of the disease, abnormal expression of cytokines will help determine the degree of disease activity and guide clinical immunotherapy. This article reviews the progress of the following cytokines IL-10, IL-12, IL-18, IFN-γ, IL-17 and IL-6.