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目的:探讨异基因造血干细胞移植(allo-HSCT)后,巨细胞病毒(CMV)感染的发病情况及抗病毒治疗的疗效。方法:对在我所接受allo-HSCT的患者23例进行回顾性分析,均应用荧光定量PCR法(FQ-PCR法)检测外周血CMV-DNA含量。CMV感染应用更昔洛韦(GCV)10mg.kg-1.d-1进行治疗。结果:23例患者中7例移植后发生CMV感染,占30.43%。GCV治疗的总有效率约为85.71%。6例在GCV治疗过程中出现白细胞和血小板减少。结论:FQ-PCR法可以应用于allo-HSCT后早期准确诊断CMV感染。GCV对allo-HSCT后CMV感染的预防及治疗效果可靠。
Objective: To investigate the incidence of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and the effect of antiviral therapy. METHODS: Twenty-three patients with allo-HSCT were retrospectively analyzed. The levels of CMV-DNA in peripheral blood were measured by fluorescence quantitative PCR (FQ-PCR). CMV infection with ganciclovir (GCV) 10mg.kg-1.d-1 for treatment. Results: CMV infection occurred in 7 of 23 patients (30.43%). The total effective rate of GCV treatment was about 85.71%. Six patients experienced leukopenia and thrombocytopenia during GCV treatment. Conclusion: The FQ-PCR method can be applied to allo-HSCT early accurate diagnosis of CMV infection. GCV on allo-HSCT CMV infection prevention and treatment of reliable results.