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目的考察金嗓口服液长期给药对大鼠的影响,为临床安全用药提供科学依据。方法将大鼠随机分为对照组,低、中、高[1,5,10 mg/(kg.d)]剂量组,灌胃30 d后,各组随机处死雌雄大鼠5只,取尾静脉血测定血红蛋白、白细胞计数、淋巴细胞百分比;解剖动物观察各脏器情况,计算脏器相对质量,对心、肝、肾、肺作组织病理学检查。其余大鼠停药继续喂养观察10 d,于停药后第11天处死作组织病理学检查。结果连续给药30 d后,各剂量组动物的体重、脏器相对质量、血常规未发生变化。病理组织学检查,各剂量组动物的心、肝、肾、肺均未见明显的病理改变。结论金嗓口服液长期用药无毒性反应。
Objective To investigate the effects of long-term administration of Golden Throat Oral Liquid on rats and provide a scientific basis for clinical safety. Methods The rats were randomly divided into control, low, middle and high [1,5,10 mg / (kg · d)] groups. After 30 days of intragastric administration, 5 male and 6 female rats were randomly sacrificed, Venous blood was measured hemoglobin, white blood cell count, lymphocyte percentage; dissected animals were observed in various organs, calculate the relative quality of organs, the heart, liver, kidney and lung for histopathological examination. The remaining rats were stopped feeding for 10 days, and were sacrificed on day 11 for histopathology. Results After 30 days of continuous administration, the body weight, relative quality of organs and blood routine in each dose group did not change. Histopathological examination showed no obvious pathological changes in the heart, liver, kidney and lung of each dose group. Conclusion Golden Throat oral medication long-term drug-free response.