目的:了解流感疫苗的安全性。方法:对我院2003年9月-12月接受流感疫苗接种的1325例医务人员进行调查,包括接种人员基本情况、不良反应(A R)发生率、程度、转归等进行统计分析。结果:1325例接种者中A R发生率55.32%(733/1325),其中局部反应占77.36%(570/733),持续时间中位数为3d,全身反应42.43%(311/733),持续时间中位数为2d;AR程度为轻度和中度,而且轻度居多(57.57%);所有发生AR者均自愈或治愈(其中自愈302例,治愈431例)。结论:接种流感疫苗后AR发生率虽较高,但多为轻度反应,持续时间短,均能自愈或治愈,比较安全。 Purpose: To understand the safety of the flu vaccine. Methods: A total of 1325 medical staff receiving flu vaccination in our hospital from September to December 2003 were investigated, including the basic situation of vaccination personnel, the incidence, degree and outcome of adverse reactions (A R). Results: The incidence of AR in 1325 vaccination patients was 55.32% (733/1325), of which 77.36% (570/733) were local reactions, with a median duration of 3d and 42.43% (311/733) of systemic reaction duration The median was 2d. The degree of AR was mild and moderate, and mild (57.57%). All AR patients were self-healing or cured (302 spontaneous and 431 cured). Conclusion: The incidence of AR after vaccination is high, but mostly mild reaction, short duration, both self-healing or cure, safer.