伊万·米哈伊洛维奇·谢切诺夫于1862年发现中枢抑制,表明刺激蟾蜍间脑或延髓会引起反射抑制,但其分子机制尚待阐明.本研究依照谢切诺夫抑制实验,用酒精和去甲肾上腺素(noradrenalin,NA)以及其他神经递质刺激蟾蜍间脑,发现急性施加酒精或去甲肾上腺素与谢切诺夫抑制相同,会兴奋间脑并引起屈腿反射时的延长.结果表明,α-肾上腺素受体应参与了中枢抑制的过程,揭示急性施加酒精引发反射抑制的可能机制. Ivan Mikhailovich Schechernov discovered central suppression in 1862, suggesting that stimulating the toad brain or medulla oblongata may cause reflex inhibition, but its molecular mechanism remains to be elucidated.This study was conducted in accordance with the Schangerov Suppression Experiment , Stimulated the toad interneurons with alcohol and noradrenalin (NA) and other neurotransmitters and found that acute administration of alcohol or norepinephrine was similar to that of Schaechninov and excitated the diencephalon and induced flexion and leg reflexes The results show that α-adrenoceptor should participate in the process of central inhibition, revealing the possible mechanism of acute application of alcohol-induced reflex inhibition.