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目的:探讨卵巢储备功能正常者采用激动剂长方案和拮抗剂方案促排卵对体外受精周期妊娠结局的影响。方法:回顾性分析卵巢储备功能正常者进行体外受精-胚胎移植(IVF-ET)的265个周期。根据促排卵方案不同将其分为:激动剂长方案促排卵组(长方案组,157个周期),拮抗剂方案组(拮抗剂组,108个周期)。结果:患者的年龄、不孕年限、体质量指数(BMI)、基础性激素水平等一般情况组间均无统计学差异(P>0.05)。hCG注射日直径14 mm以上的卵泡数、hCG注射日E2水平、平均移植胚胎数及胚胎质量、受精率、生化妊娠率、早期流产率等组间均亦无统计学差异(P>0.05);但获卵数(12.6±4.6 vs 10.8±4.6)、可用胚胎数(5.0±3.0 vs 4.2±2.7)、胚胎种植率(29.87%vs 20.98%)、临床妊娠率(42.76%vs 28.70%)长方案组明显高于拮抗剂组,差异有统计学意义(P<0.05)。结论:卵巢储备功能正常者拮抗剂促排卵,其胚胎种植率、临床妊娠率明显低于长方案组。
OBJECTIVE: To investigate the effect of ovulation induction on IVF pregnancy outcome using long-term agonist regimen and antagonist regimen in patients with normal ovarian reserve. Methods: 265 cycles of in vitro fertilization-embryo transfer (IVF-ET) were retrospectively analyzed. According to different ovulation induction programs, they were divided into long ovulation induction group (long-term program group, 157 cycles), and antagonist group (antagonist group, 108 cycles). Results: There was no significant difference between the two groups in general conditions such as age, duration of infertility, body mass index (BMI), and basic hormone levels (P> 0.05). The number of follicles more than 14 mm in diameter on day of injection, the level of E2 on hCG injection day, the average number of embryos transferred and embryo quality, fertilization rate, biochemical pregnancy rate and early miscarriage rate were also not statistically different (P> 0.05). However, the number of oocytes retrieved (12.6 ± 4.6 vs 10.8 ± 4.6), the number of available embryos (5.0 ± 3.0 vs 4.2 ± 2.7), embryo implantation rate (29.87% vs 20.98%) and clinical pregnancy rate (42.76% vs 28.70% Group was significantly higher than the antagonist group, the difference was statistically significant (P <0.05). Conclusion: Ovarian reserve function is normal antagonist ovulation, the embryo implantation rate, clinical pregnancy rate was significantly lower than the long-term plan group.