论文部分内容阅读
目的:探讨下呼吸道感染病原菌的耐药性及用药合理性。方法:分析2011年1月~2013年1月我院收治的500例下呼吸道感染病人,进行菌株鉴定和药敏试验。结果:排除重复菌株后共分离出菌株319株。肺炎链球菌对克林霉素、红霉素和复方新诺明耐药性较高,分别为87.9%、93.9%和97.0%。金黄色葡萄球菌对青霉素和克林霉素耐药性较高,分别为93.8%和50.0%。肺炎克雷伯菌对红霉素和左氟沙星耐药性较高,分别为83.9%和73.6%。大肠埃希菌对红霉素、左氟沙星和亚胺培南耐药性较高,分别为87.7%、66.1%和56.9%。结论:针对病原菌间耐药性的差异进行药物选择能够有效提高疗效,避免滥用抗菌药物。
Objective: To investigate the drug resistance and medication rationality of pathogenic bacteria in lower respiratory tract infection. Methods: From January 2011 to January 2013, 500 cases of lower respiratory tract infection admitted to our hospital were identified for strain identification and susceptibility testing. Results: A total of 319 isolates were isolated after the repeated strains were excluded. Streptococcus pneumoniae to clindamycin, erythromycin and cotrimoxazole resistance were higher, respectively, 87.9%, 93.9% and 97.0%. Staphylococcus aureus was more resistant to penicillin and clindamycin, 93.8% and 50.0%, respectively. Klebsiella pneumoniae showed high resistance to erythromycin and levofloxacin, which were 83.9% and 73.6% respectively. Escherichia coli was more resistant to erythromycin, levofloxacin and imipenem, with 87.7%, 66.1% and 56.9%, respectively. Conclusion: The drug selection based on the difference of drug resistance among pathogens can effectively improve the curative effect and avoid the abuse of antibacterial drugs.