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目的观察神经节苷脂联合银杏达莫治疗颅脑损伤的临床疗效。方法 64例颅脑损伤患者随机分为试验组和对照组,各32例。对照组静脉滴注神经节苷脂20 m L,每天2次;试验组在对照组的基础上,静脉滴注银杏达莫10 m L,每天1次。2组患者均进行为期1个月的治疗。比较2组患者的临床疗效、日常生活能力评分和神经功能缺损程度评分,并观察2组的不良反应发生情况。结果治疗后,试验组的总有效率为96.87%,显著高于对照组的78.13%(P<0.05)。治疗后,2组患者的日常生活能力均较治疗前显著升高(P<0.05)。治疗后,试验组神经功能缺损程度评分显著低于治疗前和对照组(P<0.05)。2组患者治疗期间均无明显不良反应发生。结论神经节苷脂联合银杏达莫治疗颅脑损伤比单独应用神经节苷脂治疗的临床疗效好,不仅明显改善患者的日常生活能力情况,而且可以提高患者的生活质量。
Objective To observe the clinical curative effect of ganglioside combined with gingko dipyridamole on craniocerebral injury. Methods Sixty-four patients with craniocerebral injury were randomly divided into experimental group and control group, with 32 cases in each group. The control group received intravenous infusion of 20 m L of ganglioside twice daily. In the test group, ginkgo-dipyridamole 10 m L was administered intravenously once a day on the basis of the control group. Two groups of patients were treated for one month. The clinical curative effect, daily living ability score and neurological deficit score of the two groups were compared, and the incidence of adverse reactions in the two groups were observed. Results After treatment, the total effective rate of the experimental group was 96.87%, significantly higher than 78.13% of the control group (P <0.05). After treatment, the daily living ability of the two groups was significantly higher than that before treatment (P <0.05). After treatment, the score of neurological deficit in test group was significantly lower than that before treatment and in control group (P <0.05). No significant adverse reactions occurred in the two groups during treatment. Conclusion The ganglioside combined with ginkgo-dipyridamole is superior to ganglioside alone in the treatment of craniocerebral injury, which not only improves the daily living ability of patients but also improves the quality of life of patients.