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为了研究中药类方的配伍规律,将支持向量回归机(SVR)理论应用于类方药效预测的研究,建立了基于SVR的类方药效预测模型。根据此模型可以预测不同类方配伍的药效,对优化类方配伍及临床用药有一定的指导作用。将此模型应用于肾气丸、右归丸和右归饮3首补肾阳类方配伍规律的研究,通过模型预测得到多个配伍组的药效优于3首补肾阳类方的原方。
In order to study the law of compatibility of traditional Chinese medicine prescriptions, SVR theory was applied to the prediction of class pharmacodynamics, and the SVR-based class prescription efficacy prediction model was established. According to this model can predict the efficacy of different types of compatibility, to optimize class prescription compatibility and clinical medication has a certain guiding role. The model was applied to study the compatibility of three prescriptions of Kidney-Yang Wan, Yougui Wan and Yougui Yin. The pharmacological effects of multiple compatibility groups were better than those of three kidney-invigorating Yang prescriptions predicted by the model.