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目的探讨复方甘草酸苷联合还原型谷胱甘肽治疗肝硬化的临床疗效。方法选取2010年10月～2011年10月本院肝病科收治的乙型肝炎肝硬化患者64例,将其随机分为观察组和对照组各32例,两组均给予保肝、对症、支持、防治并发症等综合治疗,观察组在综合治疗基础上采用复方甘草酸苷注射液联合还原型谷胱甘肽注射液治疗,对照组在综合治疗的基础上采用复方甘草酸苷注射液联合门冬氨酸钾镁注射液治疗,两组疗程均为2个月。疗程结束后比较两组患者的肝功能改善情况。结果两组治疗后TbiL、ALT、AST、ALB及Child-Pugh评分均明显好转,与治疗前比较,差异有统计学意义(P<0.05);且观察组改善程度优于对照组,两组间差异亦有统计学意义(P<0.05)。结论复方甘草酸苷联合还原型谷胱甘肽治疗乙型肝炎肝硬化,疗效满意,可促进肝功能恢复,缓解病情发展。
Objective To investigate the clinical efficacy of compound glycyrrhizin combined with reduced glutathione in the treatment of liver cirrhosis. Methods Sixty-four patients with hepatitis B cirrhosis admitted from our hospital from October 2010 to October 2011 were randomly divided into observation group (32 cases) and control group (32 cases). Both groups were given hepatoprotective and symptomatic treatment , Prevention and treatment of complications and other comprehensive treatment, the observation group on the basis of comprehensive treatment with compound glycyrrhizin injection combined with reduced glutathione injection, the control group on the basis of comprehensive treatment with compound glycyrrhizin injection combined with the door Aspartate potassium magnesium injection treatment, two groups of treatment are 2 months. After the end of treatment, the improvement of liver function was compared between the two groups. Results The scores of TbiL, ALT, AST, ALB and Child-Pugh were significantly improved after treatment in both groups (P <0.05), and the improvement in observation group was better than that in control group The difference was also statistically significant (P <0.05). Conclusion Compound glycyrrhizin combined with reduced glutathione in the treatment of hepatitis B cirrhosis, with satisfactory results, can promote recovery of liver function and alleviate the progression of the disease.