抗癫痫药物对男性癫痫患者的性及生殖内分泌功能的影响,国外进行了大量的研究,本文对最常用的两种抗癫痫药物:苯妥英钠及卡马西平所致男性癫痫患者血清睾酮及雌二醇的变化、初步机理及治疗等进行了综述,目前认为:PHT可致体内aromatase酶升高,致FT转化为E_2而CBZ无此作用,其它机理相近,故在治疗上除用睾酮外,目前还尝试使用睾内脂及克罗米酚。 Antiepileptic drugs on male patients with epilepsy sexual and reproductive endocrine function, a large number of foreign studies, this article on the two most commonly used antiepileptic drugs: phenytoin sodium and carbamazepine in male patients with epilepsy serum testosterone and estrogen Alcohol changes, the initial mechanism and treatment are reviewed, the current view: PHT can cause elevated aromatase in the body, resulting in the conversion of FT to E_2 CBZ without this effect, the other mechanisms are similar, so in addition to the treatment of testosterone, the current Also try using testosterone and clomiphene.