甲状腺激素(TH)是哺乳动物脑发育过程中的重要生理调节因子,已有研究表明,其不仅促进胎鼠及新生大鼠神经干细胞(NSC)分化成少突胶质细胞,还促进少突胶质细胞的进一步成熟,最终形成神经髓鞘[1-2]。因此,探讨TH对少突胶质细胞的分化调控机制,对于深入了解中枢神经髓鞘形成障碍性 Thyroid hormone (TH) is an important physiologic regulator of mammalian brain development. Studies have shown that it not only promotes the differentiation of neural stem cells (NSCs) into oligodendrocytes in fetal and neonatal rats, but also promotes oligodendrocyte Further maturation of the cells, the final formation of nerve myelination [1-2]. Therefore, to explore the differentiation of TH on the regulation of oligodendrocyte mechanism for a deeper understanding of central nervous myelination disorders