由于人二倍体细胞狂犬疫苗价格较贵,近年来有人提出以三剂0. 1毫升疫苗作皮下注射代替三剂1. 0毫升的肌肉注射剂量,认为适用于暴露前的预防注射。而暴露前免疫在再接种时可加强免疫应答,减少在暴露后预防注射疫苗的用量和不必应用被动免疫治疗,然而最近的研究则又认为以0. 1毫升疫苗皮下注射不一定能产生满意的中和抗体滴度。为了解在偶然的情况下(注射的深浅掌握不好)以及测定用较小剂量的人二倍体细胞狂犬疫苗注射的免疫原性,因此本文作者对154例观察对象分别给予肌肉注射100%、10%或 As human diploid rabies vaccine more expensive, in recent years it was proposed that three doses of 0.1 ml vaccine for subcutaneous injection instead of three doses of 1.0 ml intramuscular injection, considered suitable for pre-exposure prophylaxis. Pre-exposure immunization may enhance the immune response at re-vaccination, reduce the amount of vaccine administered after exposure and avoid the need for passive immunotherapy, but recent studies have suggested that subcutaneous injections of 0.1 ml do not necessarily produce satisfactory Neutralizing antibody titers. In order to understand the accidental circumstances (poorly controlled injections) and the immunogenicity of rabbits vaccinated with smaller doses of human diploid cells, the authors of this study randomized 154 subjects to intramuscular injections of 100% 10% or