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目的 探讨内皮素 (ET)变化与急性脑梗死的病情发展规律。方法 选择 3 5例住院的急性脑梗死患者为研究组 ,根据梗死灶体积分为小、中、大梗死组 ;依据病情轻重分为轻、中、重型 ,每位患者分别于起病 1天、7天、14天第 2 1天进行血浆内皮素浓度的测定。并设 3 0例同期健康者为正常对照组。结果 脑梗死组急性期ET明显升高 ,2 1天时血浆ET水平仍显著升高 (P <0 .0 1) ;中、大梗死组的ET明显高于轻型者 (P <0 .0 1)。结论 ET含量的升高是脑梗死发病机制中的重要因素 ,监测ET能帮助判断急性脑梗死病情变化和评估预后 ,对脑梗死的防治起一定的临床指导作用
Objective To investigate the changes of endothelin (ET) and the development of acute cerebral infarction. Methods A total of 35 hospitalized patients with acute cerebral infarction were selected as the study group and divided into small, medium and large infarct groups according to the volume of infarction. According to the severity of the disease, the patients were divided into mild, moderate and severe cases, 7 days, 14 days on the 21st day plasma endothelin concentrations were measured. And set 30 cases of normal people as normal control group. Results ET in acute cerebral infarction group was significantly higher than that in mild group (P <0.01), and the level of plasma ET was still significantly increased on day 21 (P <0.01) . Conclusions The increase of ET content is an important factor in the pathogenesis of cerebral infarction. Monitoring ET can help to judge the change of disease and evaluate the prognosis of acute cerebral infarction, and play a certain clinical guiding role in the prevention and treatment of cerebral infarction